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DFE pharma

DFE Pharma is a global leader in excipient solutions for the pharmaceutical and dietary supplements industries. With a worldwide presence, the company operates sales offices in Brazil, China, Germany, India, Japan, Singapore, and the United States, and maintains production facilities in Germany, India, the Netherlands, and New Zealand.
DFE Pharma specializes in the development, production, and supply of high-quality functional excipients. Our extensive portfolio includes more than 200 products, widely used in the development of inhalation, oral solid dosage (OSD), ophthalmic, and parenteral formulations, serving the pharmaceutical, biopharmaceutical, and dietary supplements industries.
DFE Pharma's excipients play a critical role in numerous medicines and health products, including their application in COVID-19 vaccines and related therapeutics drug products.
For more information, please visit: https://dfepharma.com

Product Name Category Characteristic & Application CDMF status
Respitose® ML001
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Respitose® ML003
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 400
Milled Lactose(Inhalation)
It is a milled, anhydrous lactose grade with a median particle size of 100μm. The coarse milled lactose grade could be used in Dry Powder Inhalation (DPI) applications where a relatively good flow with some cohesiveness is required. Its anhydrous nature makes this a unique product in DFE portfolio.
Lactohale® 300
Microfine Lactose(Inhalation)
It is a very fine micronized lactose with a D50 below 5 microns. LH300 can be utilised within a Dry powder inhalation formulation to improve the drug deposition. Improved deposition can be obtained in several ways by the introduction of fines. In addition, by blending Lactohale® 300 with selected coarse lactose grades a specific lactose blend can be developed to achieve your target product profile.
BioHale® Sucrose
Sucrose(Inhalation)
Multiple technologies for nasal and pulmonary drug delivery of active pharmaceutical ingredients exist. For the design of carrier-free formulations, spray drying has emerged as the preferred technology. Spray drying can be used to modify the particle surface, shape and density. An advantage of spray drying is that excipients, like the Biohale® grades, can be incorporated to modify aerosolization and flow properties, as well as to modify the drug release.
BioHale® Trehalose Dihydrate
Trehalose Dihydrate (Inhalation)
Multiple technologies for nasal and pulmonary drug delivery of active pharmaceutical ingredients exist. For the design of carrier-free formulations, spray drying has emerged as the preferred technology. Spray drying can be used to modify the particle surface, shape and density. An advantage of spray drying is that excipients, like the Biohale® grades, can be incorporated to modify aerosolization and flow properties, as well as to modify the drug release.
Prejel PA5 PH
Fully pregelatinized starch
Prejel PA5 PH is non-GMO, fully pregelatinized starch. It is a cost-effective excipient with a long history of usage as a binder for dry and wet addition in wet granulation. As a binder, Prejel PA5 PH enables the formation of tablets characterized by high tensile strength with low friability. Prejel PA5 PH is a high purity grade of starch that contains low levels of proteins and fats.
Respitose® SV014
Sieved Lactose(Inhalation)
Sieved inhalation lactose is a crystalline lactose with tomahawk-shaped particles having smooth surface and good flow properties. Varying degrees of particle sizes have been achieved by sieving, allowing our customers to choose the best grade fitting their formulation need.
Lactohale® 200
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 201
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 206
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 210
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 220
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Lactohale® 230
Milled Lactose(Inhalation)
Milled inhalation lactose is a highly consistent crystalline lactose with irregular-shaped particles and cohesive flow properties. Lactose is mechanically milled to varying degrees of particle size. This will allow pharmaceutical companies to choose the best grade fitting their formulation needs. Milled lactose grades consist of irregular shaped particles with a controlled particle size. Milled lactose typically has a broad particle size distribution, with lower median particle size than sieved lactose. Due to its fine nature and relatively high surface area, the flow of milled lactose is classified as cohesive to very cohesive.
Pharmatose 300M
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 350M NZ
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 350M
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 450M
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Microfine
Microfine Lactose
Micronised lactose has extremely small particles (90% is less than 10 micron). The product is used to create a pre-blend with the API to prevent segregation.
Lactopress Granulated
Granulated lactose
Agglomerated monohydrate lactose is highly consistent, the processed utilising a unique production technology. The granule structure (containing small primary particle sizes), as a result of fluid bed processing, provides optimal flow / compaction ratio allowing easy direct compression processing. lt is a product with ideal mixing properties for low to high dose formulations and will contribute to an efficient development process due to it is highly stable properties.
SuperTab 30GR
Granulated lactose
Agglomerated monohydrate lactose is highly consistent, the processed utilising a unique production technology. The granule structure (containing small primary particle sizes), as a result of fluid bed processing, provides optimal flow / compaction ratio allowing easy direct compression processing. lt is a product with ideal mixing properties for low to high dose formulations and will contribute to an efficient development process due to it is highly stable properties.
SuperTab 40LL
Granulated lactose
SuperTab® 40LL is a co-processed product that combines the critical functionalities of enhanced flow, superior compaction and high dispersibility into one single ingredient. Consequently, it expands the limits of direct compression, making it the ingredient of choice for mini-tablets and other challenging nutraceutical formulations.
Lactopress Spray-dried 250
Spray Dried Lactose
Spray dried lactose is highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. They are developed to combine the high compactability of finely milled lactose with good flow properties of spherical spray-dried particles. Especially for low dose formulation, spray-dried lactose from DFE Pharma is well suited to ensure content uniformity. This lactose type is typically used for tablet and capsule formulations.
Lactopress Spray-dried
Spray Dried Lactose
Spray dried lactose is highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. They are developed to combine the high compactability of finely milled lactose with good flow properties of spherical spray-dried particles. Especially for low dose formulation, spray-dried lactose from DFE Pharma is well suited to ensure content uniformity. This lactose type is typically used for tablet and capsule formulations.
SuperTab 11SD
Spray Dried Lactose
Spray dried lactose is highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. They are developed to combine the high compactability of finely milled lactose with good flow properties of spherical spray-dried particles. Especially for low dose formulation, spray-dried lactose from DFE Pharma is well suited to ensure content uniformity. This lactose type is typically used for tablet and capsule formulations.
SuperTab 11SD NZ
Spray Dried Lactose
Spray dried lactose is highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. They are developed to combine the high compactability of finely milled lactose with good flow properties of spherical spray-dried particles. Especially for low dose formulation, spray-dried lactose from DFE Pharma is well suited to ensure content uniformity. This lactose type is typically used for tablet and capsule formulations.
SuperTab 14SD
Spray Dried Lactose
Spray dried lactose is highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. They are developed to combine the high compactability of finely milled lactose with good flow properties of spherical spray-dried particles. Especially for low dose formulation, spray-dried lactose from DFE Pharma is well suited to ensure content uniformity. This lactose type is typically used for tablet and capsule formulations.
SuperTab 50 ODT
Spray Dried Lactose
SuperTab® 50 ODT is a highly consistent, monohydrate lactose. Due to the porous nature, fast disintegration time can be established. These attributes of SuperTab® 50 ODT, in combination with a superdisintegrant, offer rapid disintegration in the mouth. Therefore SuperTab® 50 ODT is found to be the ideal solution for oral disintegrating tablets (ODT) where fast disintegration and good mouth feel is of key importance.
Lactopress Anhydrous
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
Lactopress Anhydrous Powder
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
Lactopress Anhydrous Fine Powder
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
SuperTab 21AN
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
SuperTab 22AN
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
SuperTab 24AN
Granulated anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
SuperTab 40LL
Anhydrous lactose
A solution of lactose is rapidly dried at high temperature to form anhydrous lactose which is then milled and sieved to the required particle size distribution. Anhydrous lactose offers the best compactability of all grades of lactose, and it is well suited to direct compression applications. Anhydrous lactose is also well suited for formulations containing moisture sensitive drugs, due to the absence of crystal water. It is the recommended form of lactose for dry granulation because its brittle nature allows re-compaction without loss of tabletability.
Lactohale® 100
Sieved Lactose(Inhalation)
Sieved inhalation lactose is a crystalline lactose with tomahawk-shaped particles having smooth surface and good flow properties. Varying degrees of particle sizes have been achieved by sieving, allowing our customers to choose the best grade fitting their formulation need.
Respitose® SV001
Sieved Lactose(Inhalation)
Sieved inhalation lactose is a crystalline lactose with tomahawk-shaped particles having smooth surface and good flow properties. Varying degrees of particle sizes have been achieved by sieving, allowing our customers to choose the best grade fitting their formulation need.
Respitose® SV003
Sieved Lactose(Inhalation)
Sieved inhalation lactose is a crystalline lactose with tomahawk-shaped particles having smooth surface and good flow properties. Varying degrees of particle sizes have been achieved by sieving, allowing our customers to choose the best grade fitting their formulation need.
Respitose® SV010
Sieved Lactose(Inhalation)
Sieved inhalation lactose is a crystalline lactose with tomahawk-shaped particles having smooth surface and good flow properties. Varying degrees of particle sizes have been achieved by sieving, allowing our customers to choose the best grade fitting their formulation need.
Lactochem Fine Crystals
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Lactochem Crystals
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 50M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 60M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 70M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 80M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 90M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 100M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 110M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Pharmatose 125M
Sieved Lactose
Sieved lactose monohydrate grades. Lactose is sieved to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Pharmaceutical α-lactose monohydrate is sieved, contributing to formulations where flow is of key importance. This lactose type is typically used for sachets and capsule filling.
Lactochem Coarse Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Regular Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Fine Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Extra Fine Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Super Fine Powder
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Lactochem Regular Powder Injectable lactose
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 130M NZ
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 150M
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 200M
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
Pharmatose 200M NZ
Milled Lactose
Milled lactose monohydrate grades. Lactose is mechanically milled to varying degrees of particle sizes allowing pharmaceutical companies to choose the grade best fitting their formulation needs. Due to its fine nature and relatively high surface area, milled lactose compacts well. This lactose type is typically used in tablets, capsules and extrusion spheronisation.
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